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Scientific Reports - DanCARD:

Scientific report 2013

Mid-term report 2012

Scientific report 2011

Scientific report 2010  

Peer-review articles:

Bahnsen, J.S., Franzyk, H., Sandberg-Schaal, Nielsen, H.M.
Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
BBA Biomembranes (2013) 1828: 223-232.

Bojer, M.S., Jakobsen, H., Struve, C., Krogfelt, K.A., and Løbner-Olesen, A. 
Lack of hfq attenuates  virulence of several Escherichia coli pathotypes towards Caenorhabditis elegans. 
Microbes and Infection, 14, (2012) 1034-1039

En gruppe mennesker i et arbejdsmøde

Fazzini, R.B., Skindersoe, M., Bielecki, P., Puchaka, J., Givskov, M., and Martins dos Santos, V.
Protoanemonin: a new natural quorum sensing inhibitor that selectively activates iron starvation response.
Environ Microbiol. (2013) Jan;15(1):111-20.

Gjødsbøl, K., Skindersoe, M.E., Skov, R.L. and Krogfelt, K.A.
Cross-contamination: comparison of nasal and chronic leg ulcer Staphylococcus aureus strains.
Open Microbiol. J. (2013) 7:6-8.

Gjødsbøl, K., Skindersoe, M.E., Christensen, J.J., Karlsmark, T., Jørgensen, B., Jensen, A.M., Klein, B.M., Sonnested, M.K., Krogfelt, K.A.
No need for biopsies: Comparison of three sample techniques for wound microbiota determination.
Int Wound J. (2012) Jun;9(3):295-302.

Gómez Lozano, M., Marvig, R. L., Molin, S., and Long, K. S.
Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa.
Environmental Microbiology (2012) 14, 2006-2016.

Gómez Lozano, M., Marvig, R. L., Molin, S., and Long, K. S.
Identification of bacterial small RNAs by RNA sequencing.
Accepted for publication in Methods in Pseudomonas aeruginosa. (2013)

Jahnsen, R., Frimodt-Møller, N., Franzyk, H.
Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones.
J. Med. Chem. (2012), 55, 7253-7261.

Jahnsen, R. D.,  Haney, E. F., Franzyk, H., Hancock, R. E. W.
Characterization of a proteolytically stable multifunctional host defense peptidomimetic.
Chem. & Biol. (2013) 20:1286-1295.

Jahnsen, R. D.,  Sandberg-Schaal, A.,  Vissing, K. J., Nielsen, H. M., Frimodt-Møller, N., Franzyk, H.
Tailoring cytotoxicity of antimicrobial peptidomimetics with high activity against multidrug-resistant Escherichia coli.
J. Med. Chem. (2014) 57:2864–2873.

Jakobsen L, Andersen AS, Friis-Møller A, Jørgensen B, Krogfelt KA, Frimodt-Møller N.
Silver resistance: an alarming public health concern?
Int J Antimicrob Agents. (2011) Nov;38(5):454-5. doi:

Jakobsen, H., Bojer, M.S., Marinus, M.G., Struve, C., Krogfelt, K.A., and Løbner-Olesen, A.
The Alkaloid Compound Harmane Increases the Lifespan of Caenorhabditis elegans During Bacterial Infection, by Modulating the Nematode's Innate Immune Response.
PLoS ONE, Manus no. PONE-D-12-28454 (2012)

Jakobsen, TH,  van Gennip, M,  Phipps RK, Shanmugham, MS, Christensen, LD, Alhede, M, Skindersoe, ME, Rasmussen TB, Friedrich, K, Uthe, F,Moser, C, Jensen PO, Nielsen KF, Eberl, L, Larsen TO, Tanner, D, Højby, N, Bjarnsholt, T, and Givskov, M.
Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing.
Antimicrob Agents Chemother. (2012) May;56(5):2314-25.

Jakobsen, TH, Bragason, SK, Phipps, RK, van Gennip M, Christensen, LD, Alhede M, Skindersoe ME, Larsen TO, Høiby, N, Bjarnsholt, T, Givskov, M.
Food as a source for QS inhibitors: Iberin from Horseradish Revealed as a Quorum Sensing Inhibitor of Pseudomonas aeruginosa.
Appl Environ Microbiol. 2012 Apr;78(7):2410-21

Jansåker, F., Frimodt-Møller, N., Sjögren, I., Knudsen, J. D.
Clinical and bacteriological effects of pivmecillinam for ESBL-producing Escherichia coli or Klebsiella pneumoniae in urinary tract infections.
J. Antimicrob. Chemother. (2013) 69:769-72.

Koch, B., Ma, X., and Løbner-Olesen, A. 
rctB mutations that increase copy number of Vibrio cholerae oriCII in Escherichia coli
Plasmid, (2012) 68, 159-169

Kjelstrup, S., Hansen, P. M. P., Thomsen, L. E., Hansen, P. R., Løbner-Olesen, A.
Cyclic Peptide Inhibitors of the b-Sliding Clamp in Staphylococcus aureus.
PLoS ONE (2013) 8:e72273.

Maaland, M. G., Guardabassi, L., Papich, M. G.
Minocycline pharmacokinetics and pharmacodynamics in dogs: dosage recommendations for treatment of methicillin-resistant Staphylococcus pseudintermedius infections.
Vet Dermatol. (2014) 25:182-90, e46-7

Maaland, M. G., Papich, M. G., Turnidge, J., Guardabassi, L.
Pharmacodynamics of doxycycline and tetracycline against Staphylococcus pseudintermedius: proposal of canine-specific breakpoints for doxycycline.
J. Clin. Microbiol. (2013) 51:3547–3554.

Munk, J. K., Ritz, C., Fliedner, F. P., Frimodt-Møller, N., Hansen, P.R.
Novel method to identify the optimal antimicrobial peptide in a combination matrix using anoplin as an example.
Antimicrob. Agents Chemother. (2014) 58:1063-1070.

Munk, J. K., Uggerhøj, L. E., Poulsen, T. J., Frimodt-Møller, N., Wimmer, R., Nyberg, N. T., Hansen, P. R.
Synthetic analogs of anoplin show improved antimicrobial activities.
J. Pept. Sci. (2013) 19: 669-75.

Münch, D., Müller, A., Schneider, T., Kohl B., Wenzel, M., Bandow, J., Maffioli, S., Sosio, M., Donadio, S., Wimmer, R., Sahl, H. G.
The lantibiotic NAI-107 binds to bactoprenol bound cell wall precursors and impairs membrane functions.
J. Biol. Chem. (2014) 25:12063-12076.

Nielsen, K. L., Dynesen, P., Larsen, P., Frimodt-Møller, N.
Faecal Escherichia coli from Patients with E. coli Urinary Tract Infection (UTI) and Healthy Controls who Have Never a Had UTI.
J. Med. Microbiol. (2014) 63:582-589.

Nielsen, K. L., Dynesen, P., Larsen, P., Jakobsen, L., Andersen, P. S., Frimodt-Møller, N.
The Role of Urinary Cathelicidin (LL-37) and Human β-defensin 1 (hBD-1) in Uncomplicated Escherichia coli Urinary Tract Infections.
Infect. Immun. (2014) 82:1572-1578.

Nygaard M.K., Andersen A.S., Kristensen H.H., Krogfelt K.A., Fojan P. and Wimmer R. 
The insect defensinlucifensin from Luciliasericata
J.Biomol. (2012) NMR52(3), p. 277-282

Pieters, R. J., Slotved, H. C., Mortensen, H. M., Arler, L., Finne, J., Haataja, S., Joosten, J. A. F., Branderhorst, H. M., Krogfelt, K. A.
Use of tetravalent galabiose for inhibition of Streptococcus suis serotype 2 infection in a mouse model.
Biology (2013) 2:702-718

Schoster A, Guardabassi L, Kokotovic B.
Reduction of Beta2Toxin Gene Expression of C. Perfringens by the cell free supernatant of sour Lactobacillus strains and Bifidobacterium Animalis ssp Lactis
(Submitted to BMC Research Notes, under review).

Skindersoe, ME., Kjaerulff, S.
Comparison of three thiol probes for determination of apoptosis related changes in cellular redox status.
Cytometry A. (2014) 85:179-87.

Skindersoe, ME., Rohde, M., Kjaerulff, S.
A novel rapid apoptosis assay based on thiol redox status.
Cytometry A, (2012) 81A: 430-436, selected for video highlight http://www.youtube.com/watch?v=eFJXETLbSjg&feature=plcp

van der Plas, M. J. A., Andersen, A. S., Nazir, S., van Tilburg, N. H., Oestergaard, P. R., Dohmen, F., Krogfelt, K. A., van Dissel, J. T., Hensbergen, P. J., Bertina, R. M., Nibbering, P. H. 
A novel serine protease secreted by medicinal maggots enhances plasminogen activator-induced fibrinolysis.
Plos One (2014) 9:e92096.

Other articles:

 

Bahnsen, J. S., Water, J.  J., Franzyk, H., Nielsen, H. M.
Håb om at ramme latente bakterier i deres skjul
Lægemiddelforskning 2012, 12-14.

Munk, J. K., Hansen, P. R., Franzyk, H.
Antimikrobielle peptider: Et nyt våben mod multiresistente bakterier.
Lægemiddelforskning  (2012), 9-11.  Retrieved from http://www.farma.ku.dk/index.php/Et-nyt-vaaben-mod-multiresiste/11788/0/

 

Book chapters:

 

Hansen, P. R., Munk, J.
Synthesis of Antimicrobial Peptoids. (2013)
In Methods in Molecular Biology. New York, NY: Springer.

 

Abstracts:

 

Bahnsen,  J. S., Franzyk H., Sandberg-Schaal, A. and Hanne M. Nielsen.
Cell-penetrating Peptides Targeting Intracellular Infections
Controlled Release Society Annual Meeting, July 2013.

Bahnsen, Jesper Søborg, Henrik Franzyk and Hanne Mørck Nielsen.
The antimicrobial and cell-penetrating effects of the CPP penetratin and derived analoges
Zing Peptide Therapeutics Conference, Lanzarote, February 2012.

Bojsen, R.K., K. S. Jensen, N. Frimodt-Møller.
PKPD in vitro and in vivo of Cefotaxime (CTX) and Cefuroxime (CFR) against E. coli.
50th Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, USA. September 2010.

Damborg P, Hansen PR, Guardabassi L.
Two novel synthetic peptoids exhibit rapid in vitro killing of methicillin-resistant Staphylococcus pseudintermedius.
2nd ASM-ESCMID Conference on Methicillin-Resistant Staphylococci in Animals, Washington DC (USA), September 2011

Damborg P, Skindersø ME, Hansen PR, Bahnsen JS, Guardabassi L.
Cytotoxicity and in vivo efficacy of a novel antimicrobial peptoid against Staphylococcus pseudintermedius.
ECVPH Annual Scientific Conference 2012, Maastrict (The Netherlands), August 2012.

Gómez-Lozano, M., Marvig, R. L., Molin, S., and Long, K. S.
Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa.,
Bacteria, Archaea & Phages Meeting, Cold Spring Harbor, NY, USA, August 2012.

Gómez-Lozano, M., Marvig, R. L., Molin, S., and Long, K. S.
Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa.
International Conference on Genomics in Europe, Copenhagen, Denmark, May 2012.

Gómez-Lozano, M., Marvig, R. L., Molin, S., and Long, K. S.
Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa.
Regulatory & Non-Coding RNAs Meeting, Cold Spring Harbor, NY , USA, August-September 2012.

Gómez-Lozano, M., Marvig, R. L., Molin, S., Long, K. S.
Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa.
3rd Conference on Regulating with RNA in Bacteria, Wurzburg, Germany, June 2013.

Hansen, P.R,  and N. Frimodt-Møller.
Antimicrobial activity of small 3-(2-naphthyl)-L-alanine containing peptides.
The 31st European Peptide Symposium, Copenhagen, Denmark. September 2010.

Hertz, F. B.,  Littauer, P., Medina, A., Schønning, K., Knudsen, J.D., Loebner-Olesen, A., Frimodt-Møller, N.
Case control study of primary care urinary tract infection (UTI) caused by ESBL-producing E.coli as compared to non-ESBL E.coli either resistant or completely susceptible to antibiotics.
23rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Berlin, Germany, 2013.

Hertz, F. B.,  Nielsen, J. B., Littauer, P., Schønning, K., Knudsen, J.D., Loebner-Olesen, A., Frimodt-Møller, N.
Classification of non-ESBL E.coli isolates from urinary tract infections (UTI), from general practises.
24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, Spain, May 2014.

Jahnsen, Rasmus D., Niels Fridmodt-Møller, Henrik Franzyk.
Induction of antimicrobial activity against ESBL and NDM- 1 producing Escherichia coli by peptide backbone modifications - a comparative study.
AMP 2012, Lille, France, June 2012.

Jahnsen, Rasmus. 
Antimicrobial peptides
Gordon Research Conference, Ventura CA, USA, February 2013.

Jakobsen, L., K.S. Jensen, C. Vingsbo Lundberg, N. Frimodt-Møller.
Ciprofloxacin (CIP) PK/PD in Experimental Urinary Tract Infection (UTI) Depends on Time>MIC and not AUC24/MIC.
52nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, USA, September 2012.

Jensen, K.S., N.B. Nielsen, M. Skjønnemand, D.S. Hansen, K.H.W. Lange, N. Frimodt-Møller.
Probability of target attainment for Cefuroxime (CXM) dosage against some common bacteria.
51th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, USA, September 2011.

Kjelstrup, S. and A. Løbner.
Synthetic peptide inhibitors of DNA replication.
1st European Conference of Microbiology and Immunology, Budapest, Hungary, May 2011.

Kjelstrup, Susanne and Anders Løbner-Olesen.
Synthetic peptide inhibitors of DNA replication.
Keystone  Symposium, Antibiotics and Resistance: Challenges and Solutions, Santa Fe, USA:,  February 2010

Kolja M. Knapp, Rasmus Jahnsen, Henrik Franzyk.
Comparative study of antibacterial alfa- and beta-peptoid/alfa-peptide chimeras
31st European Peptide Symposium, Copenhagen, September 2010.

Krogfelt, K.A.
Antibacterial activity of phospholipids.
Physician's Round Table, Tampa, Florida, USA, January 2013

Løbner-Olesen, Anders.
Synthetic circular peptides that interfere with protein-protein interaction: isolation of inhibitors of the S. aureus replisome.
BITs 1th annual symposium on antimicrobial research, Beijing, China, November 2011.

Minoia M, Bortolaia V, Guardabassi L.
Effects of Cephalosporins on Conjugation of IncI1 Plasmid Encoding CMY-2 β-lactamase.
9th International Symposium On Antimicrobial Agents And Resistance (ISAAR), Kuala Lumpur, Malaysia, March 2013.

Minoia M, Bortolaia V, Villa L, Carattoli A, Guardabassi L.
Effects of Cephalosporins on Conjugation of IncI1 Plasmid Encoding CMY-2 β-lactamase.
53rd Interscience Conference on 
Antimicrobial Agents and Chemotherapy (ICAAC), Denver, CO, USA, September 2013.

Mo, S. S., Maaland, M.G., Schwarz, S., Guardabassi, L.
Chloramphenicol and florfenicol MIC distributions, genetic resistance markers and time-kill kinetics in canine clinical isolates of Staphylococcus pseudintermedius.
3rd ASM-ESCMID Conference on Methicillin-resistant Staphylococci in Animals, Copenhagen, Denmark, November 2013.

Munk, J. K., C. Ritz, L. E. Uggerhøj, T. J. Poulsen, R. Wimmer, N. Frimodt-Møller, P. R. Hansen
Statistical Design and Analysis of Anoplin Sequence Chemical Space

Munk, J. K., L. Thøgersen, L. E. Uggerhøj, R. Wimmer, N. Frimodt-Møller, K. Lindorff-Larsen, P. R. Hansen.
Correlations between biological activities and molecular dynamics of four anoplin analogs.
23rd American Peptide Symposium,  Hawaii, USA. June 2013

Munk, J. K., Thøgersen, L., Uggerhøj, L. E., Wimmer, R., Frimodt-Møller, N., Lindorff-larsen, K., Hansen, P. R.
The Structure of the Central Side Chain is Crucial for Anoplin Hemolytic Activity.
In 23rd American Peptide Symposium. Hawaii, USA, June 2013.

Munk, J. K., Ritz, C., Fliedner, F. P., Frimodt-Møller, N., & Hansen, P. R.
A Minimal Labor Approach to Identifying the Optimal Anoplin Analog using ANOVA.
In 23rd American Peptide Symposium Hawaii, USA, June 2013.

Maaland M.
Tetracycline, doxycycline and minocycline MIC distributions and genetic resistance markers in canine clinical isolates of Staphylococcus pseudintermedius
6th AAVM Conference, Washington DS (USA), October 2012.

Nälgård S, Moodley A, Vogensen F, Neve H, Guardabassi L.
Isolation and characterization of novel lytic bacteriophages against multi-drug resistant Staphylococcus pseudintermedius ST71 and ST68.
2nd ASM-ESCMID Conference on Methicillin-Resistant Staphylococci in Animals, Washington DC (USA), September 2011

Poulsen, Tanja Juul.
New Antibiotics Based on Anoplin from Wasps: Synthesis, Characterisation and Activity
Aalborg University, June 2011

Rasmussen L, Skindersoe, M. E., Krogfelt, K., Andersen, L.P.
Development of a novel assay for quantification of Helicobacter pylori cell adhesion.
10th International Workshop on Pathogenesis and Host Response in Helicobacter Infections, Helsingør, Denmark, July 2012.
 

Schoster A, Arroyo LG, Staempfli HR, Shewen PE, Weese JS.
Epidemiologic investigation of Clostridium Difficile and Clostridium perfringens in healthy horses.
Clos Path Conference, Ames (USA), October 2011

Schoster, A, Kokotovic B, Da Ballo, F, Permin A, Dedenroth P, Guardabassi L.
In-vitro growth characteristics of commercial probiotic strains and their potential for inhibition of Clostridium difficile and Clostridium perfringens.
ECVPH Annual Scientific Conference, Maastrict, The Netherlands, August 2012

Schoster, A, Kokotovic B, Permin A, Dedenroth P, Guardabassi L.
In-vitro growth characteristics of commercial probiotic strains and their potential for inhibition of Clostridium difficile and Clostridium perfringens. 
ACVIM Forum, New Orleans (USA), May 2012

Schoster, A,Guardabassi, L, Kokotovic, B. 
Reduction of Beta2Toxin Gene Expression of C. Perfringens by the Cell Free Supernatant of Four Lactobacillus Strains and Bifidobacterium Animalis SSP Lactis.
ACVIM Forum, Seattle (USA), June 2013. 

Schoster A, Guardabassi L, Kokotovic B.
Reduction of Beta2Toxin Gene Expression of C. Perfringens by the Cell Free Supernatant of Four commercial probiotic strains.
Proc ClosPath Cong, Palm Cove QLD, USA, October 2013.

Water , Jorrit J., Camilla Foged, Henrik Franzyk, Hanne M. Nielsen,
Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line
Controlled Release Society Annual Meeting, July 2013.

Water, J.J., Maltesen, M., Foged, C., Franzyk, H., Nielsen, H.M.
Hydrogel nanoparticles for delivery of short cationic antimicrobial peptides
Controlled release Society: annual meeting 2014, Chicago, Illinois, US


 

PhD Theses: 

Gómez Lozano, M.
Genome-wide identification of novel small RNAs in Pseudomonas aeruginosa.
Novo Nordisk Foundation Center for Biosustainability. 2013.

Jakobsen H.
Combating antibiotic resistance: identification of compounds targeting bacterial virulence and host innate immunity.
Statens Serum Institut/RUC. 2013.

Munk, J.K.
Structure-Activity Studies of Anoplin.
Department of Drug Design and Pharmacology. UCPH-HEALTH. 2013

Jahnsen, R. D.
Peptidomimetics as Novel Antibiotics.
Department of Drug Design and Pharmacology, UCPH-HEALTH. 2013.

Bachelor and Master Theses:  

Anja Sigl
Temocillin - an optimal treatment option for urinary tract infection?
Statens Serum Institut/Basel University, April 2012

Anja Sloth Nielsen
Metabolic profiling of pathogenic bacteria
Aalborg University, June 2011

Delima Sebamalairashan
Evaluation of gentamicin pharmacokinetics and pharmacodynamics in experimental urinary tract infection in mice.
RUC, March 2011

Frederikke Fliedner (Bachelor Thesis)
Analogues of the Antimicrobial Peptide Anoplin
UCHP-HEALTH, June 2012

Jesper Søborg Bahnsen
Characterization and optimization of truncated and structurally modified penetratin analogs.
UCPH-HEALTH, Dec 2010

Mads Erlin Nygaard Kristensen
Structural Characterization of New Antibiotics from Maggots
Aalborg University, June 2011

Maria H. Michaelsen
Formulation and characterization of AMPs for therapeutic use
UCHP-HEALTH, April 2012

Mikkel Calum
In vitro antagonism between beta-lactams and macrolides
UCPH-HEALTH/Hvidovre Hospital, Feb. 2013

Monica Hermann
Antisense sRNAs in P. aeruginosa.
DTU, expected March 2013.

Natasja M Nystrup.
Investigation of cranberry juice effects on biofilm formation.
Statens Serum Institut 2013.

Paula Melo Paulon Hansen
Synthetic Cyclic Antimicrobial Peptides.
DTU, March 2012

Ping Fang
Purification of circular peptides with antimicrobial effect and analysis by HPLC-MS.
RUC, May 2011

Rasmus K. Bojsen
Comparative investigations of cephalosporins - in vivo and in vitro study of cefuroxime and cefotaxime: bactericidalactivity, ESBL selection ability and frequency of resistance.
DTU/Statens Serum Institut. August 2010

Sofia Nälgård
Phage as a tool for control of skin infection caused by multidrug-resistant staphylococci in dogs
UCHP-HEALTH, August 2011.

Solveig Sølverød
Pharmacodynamic properties of chloramphenicol and florfenicol.
UCHP-HEALTH, April 2013.

Steffen Jørgensen
Characterization of Escherichia coli isolates causing catheter associated urinary tract infection.
Statens Serum Institut. 2013.

Tanja Juul Poulsen
New Antibiotics Based on Anoplin from Wasps: Synthesis, Characterisation and Activity 
Aalborg University, June 2011

Thea Høgh
Metabolic profiling ofpathogenic bacteria
Aalborg University, June 2012

Presentations: 
 

A. Sandberg-Schaal, F. Van Bambeke
Intra- and Extracellular activities of Anti-infective Agents
Invited experts at Meet-the-Experts session, 52th Interscience Conference on Antimicrobial Chemotherapy, San Francisco, CA, USA. September 11, 2012

L. Jakobsen, K. A. Krogfelt, N. Frimodt-Møller
Silver as a putative health concern
Conference on Nanosilver, Federal Institute for Risk Assessment, Berlin 8-9 February, 2012

A. Løbner-Olsen:
Development of synthetic circular peptides directed against DNA replication in. S. aureus
Invited speaker at the 1st Annual Symposium of Antimicrobial Research (SAR-2011), Beijing, China, December 1-3, 2011

K.S. Jensen, J. Bulitta:
Mathematical Modeling and Pharmacokinetics/Pharmacodynamics
Invited experts at Meet-the-Experts session, 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, September 2010. 

 

 

 

Last revised 16 July 2014